![]() ![]() Remarkably, silver nanoparticles have been reported to exploit antiviral influence against various viral strains including (HIV) and hepatitis B virus (HBV), macrophage (M)-tropic and T-lymphocyte (T)-tropic strains of HIV-1 and H3N2 influenza virus and Peste des petits ruminants virus (PPRV). Moreover, silver nanoparticles exhibit antifungal activity against wide spectrum of pathogenic fungal species including Candida species like Candida albicans and Candida tropical Candida glabrata and their biofilms, besides, enhancing the antibiofilm of the antifungal agent, nystatin or chlorhexidine (CHX) against Candida albicans and Candida glabrata. For each application, the study level of the device is indicated, if it is either a laboratory study or a commercial product. ![]() In addition, the fields of potential application are analyzed, demonstrating the versatility of silver nanoparticles, which can be involved in several devices and applications, including biomedical applications, considering both human and animal health, environmental applications, such as air filtration and water treatment, and for food and textile industry purposes. This review provides an overview of the antiviral properties of silver nanoparticles, along with their demonstrated mechanisms of action and factors mainly influencing their properties. Although the mechanism of antiviral action is not completely clarified, silver nanoparticles can directly act on viruses, and on their first steps of interaction with the host cell, depending on several factors, such as size, shape, functionalization and concentration. Thanks to their peculiar properties, nanomaterials play an important role in this field, and, in particular, among metallic materials, silver nanoparticles were demonstrated to be effective against a wide range of viruses, in addition to having a strong antibacterial effect. New antiviral drugs and new preventive antiviral strategies are a target of intense scientific interest. These results demonstrated that the Ag-NPs-coated PUC is able to directly inactivate the microbe's infectious ability and provides another defense line against these sexually transmitted microbial infections. Furthermore, we also showed that the Ag-NPs-coated PUC was able to inhibit the growth of bacteria and fungi. In addition, the data showed that both macrophage (M)-tropic and T lymphocyte (T)-tropic strains of HIV-1 were highly sensitive to the Ag-NPs-coated PUC. In an attempt to elucidate the antiviral action of the Ag-NPs, we have demonstrated that the anti-HIV activity was primarily mediated by the Ag-NPs, which are associated with the PUC. Interestingly, our results demonstrated that the contact of the Ag-NPs-coated PUC with HIV-1 and HSV-1/2 was able to efficiently inactivate their infectiousness. ![]() ![]() No significant toxic effects was observed when human HeLa cells, 293T and C8166 T cells were contacted to Ag-NPs-coated PUC for three hours. The NP binding is due to its interaction with the nitrogen atom of the PUC. Morphology of the PUC was retained after coating. Nanoparticles were stable on the PUC and not washed away by water. The Ag-NPs-coated PUC was characterized by using ultraviolet-visible spectrophotometry, Fourier transform-infrared spectroscopy, high-resolution scanning electron microscopy, and energy-dispersive analysis of X-ray spectroscopy. The preliminary goal of this study was to develop a silver nanoparticles (Ag-NPs)-coated polyurethane condom (PUC) and to investigate its antimicrobial potential including the inactivation of HIV and herpes simplex virus (HSV) infectiousness. The new nanotechnology-based condom holds the promise of being more potent than the first-generation products. In response, there has been a push to develop more effective ways of decreasing the spread of the disease. Recent research suggests that today's condoms are only 85% effective in preventing human immunodeficiency virus (HIV) and other sexually transmitted diseases. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |